GAO Hong's clinical experience in treatment of tic disorder with acupuncture technique of cultivating the primary and regulating the mind / 中国针灸

The paper introduces the clinical experience of GAO Hong in treatment of tic disorder. GAO Hong believes that tic disorder results from the primary qi deficiency and mind disturbance. Acupuncture for cultivating the primary and regulating the mind is proposed specially for tic disorder. This acupuncture technique focuses on harmonizing and regulating governor vessel and conception vessel. In clinical practice, the conception vessel acupoints on the abdomen and the governor vessel acupoints on the head are selected particularly, e.g. Zhongwan (CV 12), Xiawan (CV 10), Qihai (CV 6) and Guanyuan (CV 4) on the abdomen; Baihui (GV 20), Shenting (GV 24), Benshen (GB 13) and Yintang (GV 24+) on the head. The needling sequence and the insertion depth are emphasized, which affect the curative effect and GV 20 is generally punctured first. Besides, considering to the type of disorder and the affected site, tic disorder is treated in view of both syndrome/pattern differentiation and symptom differentiation.

A Reflection on the 2017 Nobel Prize for Physiology and Chinese Medicine / 中国结合医学杂志

Research on the molecular mechanisms controlling circadian rhythm in Western medicine is comparable to the study of a day-night rhythm in Chinese medicine (CM), as also focus on the same life phenomenon. By comparing the two, this paper elaborates on the differences between them in their respective issues of consciousness, ways of thinking, research methods and research results. Relatively speaking, Nobel Prize research has a stronger sense of the problems and concerns about the essence of "what", while CM focuses on "how a thing functions". The former mainly adopts experimental and mathematical methods, while the latter primarily depends on observation and understanding. The natural philosophy and natural science eventually lead to the results and the inevitable, quantitative and qualitative differences. Research on the life rhythm in CM should be proposed, scientific problems should be fully grasped, and research should be carried out with the aid of multidisciplinary new knowledge and new achievements through cross-disciplinary studies. On the basis of clinical epidemiological research and experimental research, a systematic review should be made of the human physiology of CM and the pathological rhythm model to explore the regulatory mechanism of time rhythm and create a new theory of time medicine.

Effect of inflammatory factor and neurotransmitter of Yizhi Xingnao Fang combined with western medicine for patients with alzheimer's disease / 中国免疫学杂志

Objective:To study the effect of inflammatory factor and neurotransmitter of Yizhi Xingnao Fang combined with western medicine for patients with alzheimer's disease. Methods:124 cases alzheimer's patients from October 2014 to October 2016 were divided into observation group and control group,the control group given donepezil etc conventional western medicine therapy,ob-servation group given Yizhi Xingnao Fang combinde with western medicine therapy. 12 weeks after treatment,cerebrospinal fluid in-flammatory factors,neurotransmitter and clinical efficacy were compared between two groups. Results:Observation group effective rate 80.65% was significantly higher than control group 64.52% (X2= 4.052 9,P<0.05);cerebrospinal fluid TNF-α,IL-6 were significantly lower than control group,IL-4,IL-10 were significantly higher than control group (t=10.911,8.739,5.000,4.046,P<0.05,P<0.01);DA,5-HT,NE were significantly higher than control group(t=9.435,7.916,5.985,P<0.05,P<0.01). Conclusion:Yizhi Xingnao Fang combined with western medicine therapy help to improve the clinical symptoms and therapeutic effect,which may be related to the suppression of inflammatory symptoms,regulation of neurotransmitter expression level.

Pharmacokinetics of the combined preparation of lisinopril and hydrochlorothiazide on Chinese healthy volunteers / 药学学报

The aim of the present study, performed on two different groups of volunteers, is to characterize the pharmacokinetics of lisinopril/hydrochlorothiazide combined tablet. After administration of high, medium and low doses of lisinopril/hydrochlorothiazide combined tablets, AUC and C(max) of two compounds both increase significantly with increase of dose. Neither normalized AUC/Dose nor C(max)/Dose has significant difference between every two tested dose groups. The similar results can be observed as for the parameters of t(max). Lisinopril and hydrochlorothiazide are both eliminated with linear characteristics. After repeated administration of lisinopril/hydrochlorothiazide combined tablets, AUC, C(max) and C(min) of lisinopril in the steady state increase. AUC and C(min) increase significantly. As for hydrochlorothiazide, AUC, C(max), C(min), and t(max) also increase in steady state. AUC and C(min) increase significantly. Administered with the test medication, lisinopril has an fluctuation index (FI) value of 2.29 and reaches a relative steady concentration. But hydrochlorothiazide has an FI value of 4.09 with relatively large fluctuating concentrations.

Main dimensions of health status among the Chinese elderly / 中华预防医学杂志

<p><b>OBJECTIVE</b>To analyze the dimensions of health status among the Chinese elderly.</p><p><b>METHODS</b>Through unbalanced sampling method, 16 219 elderly aged above 65 were sampled from 22 provinces of China. The activities of daily living (ADL), physical performance, cognitive function, self-reported health and life satisfaction were investigated. We conducted comparative dimensions of health analysis across age, genders and rural/urban residences.</p><p><b>RESULTS</b>Among the male elderly aged 65-, 70-, 80-, 90- and 100-, 98.8% (730/739), 95.2% (1445/1518), 89.1% (1913/2147), 76.3% (1447/1897) and 51.6% (329/638) were ADL independent, respectively. The corresponding percentages among the female counterparts were 98.1% (654/667), 94.9% (1291/1361), 87.2% (1851/2124), 70.0% (1888/2699) and 46.8% (1136/2428), respectively (gender difference in ADL: chi(2) = 293.00, P < 0.01). Among the urban elderly aged 65-, 70-, 80-, 90- and 100-, the percentages were 98.0% (561/572), 93.6% (1090/1165), 85.5% (1413/1653), 69.3% (1311/1892) and 37.4% (434/1161) respectively. The corresponding percentages among the rural counterparts were 98.7% (823/834), 96.0% (1646/1714), 89.8% (2351/2618), 74.9% (2024/2704) and 54.1% (1031/1905) respectively (urban/rural difference in ADL: chi(2) = 85.97, P < 0.01). Among the male elderly aged 65-, 70-, 80-, 90- and 100-, 96.5% (713/739), 90.0% (1364/1516), 72.1% (1547/2145), 49.2% (929/1890) and 35.0% (218/623) had good cognitive function. The corresponding percentages among the female counterparts were 94.1% (627/666), 81.9% (1113/1359), 57.2% (1211/2116), 32.4% (870/2688), 17.5% (418/2395) respectively (gender difference in cognitive function: chi(2) = 893.89, P < 0.01). Among the urban elderly aged 65-, 70-, 80-, 90- and 100-, the percentages were 97.0% (555/572), 87.9% (1023/1164), 68.5% (1129/1648), 43.6% (820/1881) and 23.0% (258/1124) respectively. The corresponding percentages among the rural counterparts were 94.2% (785/833), 85.0% (1454/1711), 62.3% (1629/2613), 36.3% (979/2679) and 20.0% (378/1894), respectively (urban/rural difference in cognitive function: chi(2) = 57.92, P < 0.01). Among the male elderly aged 65-, 70-, 80-, 90- and 100-, the self-reported good health were 56.3% (416/739), 50.7% (770/1518), 46.0% (988/2148), 42.7% (809/1897) and 43.1% (175/638). The corresponding percentages among the female counterparts were 48.7% (325/667), 46.1% (627/1361), 43.0% (914/2124), 39.3% (1061/2699) and 34.5% (838/2428). The male elderly of each age group reported better health than the female counterparts (chi(2) = 233.91, P < 0.01). Among the male elderly aged 65-, 70-, 80-, 90- and 100-, 56.2% (415/739), 56.0% (850/1518), 55.7% (1194/2418), 52.9% (1003/1897) and 50.5% (322/638) self-reported satisfied life. The corresponding percentages among the female counterparts were 54.9% (366/667), 55.8% (759/1361), 53.9% (1144/2124), 50.6% (1365/2699) and 43.4% (1054/2428). The elderly aged 65- have no significant gender difference in self-reported life (chi(2) = 0.51, P = 0.916), while the male elderly aged 70 and above reported more satisfied life than the female counterparts (chi(2) = 218.25, P < 0.01).</p><p><b>CONCLUSION</b>Percentages of good physical performance and normal cognitive function dropped dramatically as age increased, but percentages of reporting good health and satisfied life decreased very slowly as age increased. Rural elderly were significantly more active in daily living than urban elderly. Female elderly were seriously disadvantaged in ADL, physical performance, cognitive function and self-reported health as compared with their male counterparts.</p>

Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>The most significant biological change in intervertebral disc degeneration is the decrease of chondrocyte specific gene and protein expression of Sox9 and collagen type II. Interleukin-1 (IL-1) is not expressed in the normal intervertebral disc tissue but increases in the degenerated intervertebral disc tissue. This suggests that IL-1 may play a role in regulation of the expression of Sox9 and collagen type II.</p><p><b>METHODS</b>Human intervertebral disc cells were isolated and cultured. Sox9 and collagen type II expression during treatment with IL-1, with or without the nuclear factor-kappaB (NF-kappaB) activity inhibitor curcumin, were detected by using reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, and the activity of the NF-kappaB signaling pathway was detected by the electrophoretic mobility shift assay (EMSA).</p><p><b>RESULTS</b>IL-1 lowered the mRNA level and protein expression of Sox9 and collagen type II in the cultured intervertebral disc cells in a dose dependent manner (P < 0.05), and this effect was attenuated by curcumin. Curcumin alone had no effect on Sox9 and collagen type II expression (P > 0.05). IL-1 at concentrations of 0.1 ng/ml, 1 ng/ml and 10 ng/ml could stimulate the activity of NF-kappaB in the intervertebral disc cells in a dose dependent manner (P < 0.05) that was inhibited by curcumin.</p><p><b>CONCLUSIONS</b>We demonstrated the previously unknown function of IL-1 in inhibiting Sox9 and collagen type II via NF-kappaB in the intervertebral disc cells. This inhibition can be attenuated by curcumin, which is an effective NF-kappaB activity inhibitor.</p>

Sensory Ataxia Form of Chronic Inflammatory Demyelinating Polyneuropathy / 浙江中医药大学学报

[Objective] To explore the clinical characteristics and pathogenic mechanism of sensory ataxia form of GBS.[Methods] To Summarize clinica1 data of 19 cases with sensory ataxia form of GBS.[Result] The main clinical manifestations were sensory ataxia.The disease relieved and recurred easily and had long course.The protein in CSF increased significantly.Pathological feature was same with general CIDP.Treatment of glucocortieoid was satisfied.[Conclusions] Sensory ataxia form of GBS was one sub-type of CIDP.Pathogenic mechanism was perhaps that immunoreaction attacked proproioceptive sense fibre of radix dorsalis.